14-3-3 Protects against stress-induced apoptosis
نویسندگان
چکیده
منابع مشابه
Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...
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متن کامل14-3-3 proteins in apoptosis.
The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions ...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2012
ISSN: 2041-4889
DOI: 10.1038/cddis.2012.90